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8.2.4 McLafferty Rearrangement

One common rearrangement reaction is called the McLafferty Rearrangement. The neutral product formed from this reaction is an alkene, and the active site is usually a heteroatom. Further, this reaction is typically associated with a six membered ring transition state and a hydrogen migration. To demonstrate the general mechanism of the McLafferty Rearrangement, consider the decomposition of 2-pentanone ions: {insert figure}

John S. Riley, DSB Scientific Consulting